Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Synonyms: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide CAS Number: 1360614-48-7 Molecular Formula: C18H15N5O6S2.1/2H2O Molecular Weight: 470.48 Purity: 98% (HPLC) Appearance: Supplied as a yellow solid Solubility: DMSO to 20mM Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Elemental Analysis: Calculated: %C: 45.95, %H: 3.43, %N: 14.89 Storage and Stability: May be stored at 4C. Light sensitive. Store in amber vial. Stable for 6 months after receipt.
Molecular Weight:
470.48
Purity:
98% (HPLC)
Form:
Supplied as a yellow solid
CAS Number:
[1360614-48-7]
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