Autotaxin Inhibitor I, S32826, CAS [[1103672-43-0]]
Biozol Catalog Number:
USB-256552
Supplier Catalog Number:
256552
Alternative Catalog Number:
USB-256552-5
Manufacturer:
US Biological
Category:
Biochemikalien
A phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX beta) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX beta) activities of ATX alpha/beta/gamma, while exhibiting much reduced (IC50 ~ 6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays. Synonyms: ATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate CAS No: 1103672-43-0 Molecular Formula: C21H34NO4PNa22H2O Solubility: H2O (0.5mg/ml) Appearance: White powder Purity (HPLC): 97% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.
CAS Number:
[1103672-43-0]
* VAT and and shipping costs not included. Errors and price changes excepted
