Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Melting Point: 202 - 204C TLC Conditions: Dichloromethane:Methanol:Ammonia solution (9:1:0.1), Rf = 0.76 Solubility: Soluble in methanol up to 50mM Method for Determining Identity: Proton NMR Elemental Analysis: Calculated: 67.15%, 4.78% H, 6.81% N Found: As reported Storage and Stability: Store dessicated at room temperature. For maximum recovery of product, centrifuge the original vial prior to removing the cap. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20C or below and used within 1 month. Wherever possible solutions should be made up and used on the same day.
Molecular Weight:
411.37
Purity:
99% (HPLC)
Form:
Tan solid
CAS Number:
[146662-42-2]
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