Triacsin C is a natural product that belongs to the group of macrolide antibiotics. It has been shown to inhibit the production of inflammatory cytokines and chemokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6, by binding to toll-like receptor 4. This drug also inhibits the production of inflammatory mediators, such as prostaglandin E2, in 3T3-L1 adipocytes. Triacsin C has also been shown to have antihypertensive effects through its ability to bind to ATP binding cassette transporters and inhibit the uptake of diacylglycerol into primary cells. In addition, triacsin C has been shown to have cardioprotective effects by reducing myocardial infarct size in mice and suppressing xenograft tumor growth through inhibition of angiogenesis. Synonyms: FR 900190, Triacsin C, WS 1228A, 2E,4E,7E-undecatrienal, nitrosohydrazone CAS No: 76896-80-5 Molecular Formula: C11H17N3O Molecular Weight: 207.27 Appearance: Powder Purity: 95% Solubility: DMSO: 5mg/ml, Methanol: 5mg/ml Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
207.27
Purity:
95%
Form:
Powder
CAS Number:
[76896-80-5]
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