Urantide acts as a competitice urotensin-II(UT) antagonist, blocking contractions in the thoracic aorta. Selective and competitive urotensin-II (UT) receptor antagonist pK = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors). Synonyms: L-alpha-Aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine Cyclic (27)-Disulfide CAS No: 669089-53-6 Molecular Formula: C51H66N10O12S2x(C2HO2F3) Molecular Weight: 1075.26 anhy Purity: 95% Appearance: White to off-white solid Solubility: Ethanol (Very Slightly), Methanol (Slightly), Water (Slightly) Melting Point: > 175C (dec.) Method for Determining Identity: Proton NMR Spectroscopic, F NMR Spectroscopic and Mass Spectrometric Analysis Elemental Analysis: As Reported Specific Rotation (c=0.1, Methanol): As Reported Water Content (KF): As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
1075.26
CAS Number:
[669089-53-6]
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