Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/beta-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable. CAS Number: 1243243-89-1 Formula: C25H21N3O Solubility: 20mM in DMSO and to 20mM in ethanol 1H NMR: Consistent with structure Mass Spectrum: Consistent with structure Purity: 99% Storage: Store at -20C
Purity:
99%
Form:
Supplied as a white solid.
CAS Number:
[1243243-89-1]
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