Dirithromycin is a polyvinylpyrrolidone-based drug that has an inhibitory effect on the proliferation of human polymorphonuclear leukocytes. This drug is used to treat infections caused by bacteria, such as Streptococcus pyogenes, and also has been shown to have synergistic effects with other drugs. Dirithromycin binds to the ribosomal RNA component of microbial cells and inhibits protein synthesis. It also inhibits the production of mannuronic acid in Streptococcus pyogenes, which may be related to its inhibitory properties towards human polymorphonuclear leukocytes. Dirithromycin has been shown to have genotoxic activity in vitro, but not in vivo. Synonyms: [9S(R)]-9-Deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)ethylidene]oxy]erythromycin, ASE 136, Antibiotic AS-E 136, Dirythromycin, Dynabac, KT 237216, LY 237216, Noriclan, Nortron, Valodin CAS No: 62013-04-1 Molecular Formula: C42H78N2O14 Molecular Weight: 835.07 Purity: 95% (TLC) Appearance: White to off-white solid Water (Karl Fisher): 2.5% Carbon: 57.1-63.8% Nitrogen: 3.0-3.7% Method of Determining Identity: Proton NMR Spectrum Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
835.07
Purity:
95% (TLC)
Form:
White to off-white solid
CAS Number:
[62013-04-1]
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