| Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Synonyms: Antikrein, Antilysin, Antilysine, Aprostat, Aprotinin, BPTI, BPTI Trypsin Inhibitor, Basic Pancreatic Trypsin Inhibitor, Bayer A 128, Bovine Basic Pancreatic Trypsin Inhibitor, Bovine Pancreatic Trypsin Inhibitor, Bovine Trypsin Inhibitor, Fosten, Kallikrein-trypsin Inactivator, Kiker 52G, Kir Richter, Kunitz Pancreatic Trypsin Inhibitor, Kunitz Protease Inhibitor, Kunitz Trypsin Inhibitor, Kunitz-type Inhibitor, Kunitz-type Proteinase Inhibitor, Kunitz-type Trypsin Inhibitor, Onquinin, Pancreatic Basic Trypsin Inhibitor, Pancreatic Trypsin Inhibitor, Pancreatic Trypsin Inhibitor (Kunitz), Protease Inhibitor, Kunitz Type, RP 9921, Repulson, Trasuylol, Trasylol, Trazinin, Triazinin, Trypsin Inhibitor, Trasylol, Trypsin-kallikrein Inhibitor (Kunitz), Zymofren CAS No: 9087-70-1 Source: Bovine Molecular Formula: C284H432N84O79S7 Molecular Weight: 6511.45 Appearance: White to pale yellow powder Activity: 3TIU/mg Unit Definition of Activity: One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0umol of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU. Moisture: 7% Storage and Stability: Lyophilized powder is stable for 12 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
