L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer's disease, and the secondary effects of diabetes. Synonyms: ß-Ala-His-OH, N-(beta-Alanyl)-L-histidine, NSC 524045, Sevitin, beta-Alanyl-L-histidine, beta-Alanylhistidine, Carnosine, 2: PN: WO2009033754 PAGE: 98 Claimed Protein, Dragosine, Ignotin, Ignotine, Karnozin, beta-Alanyl-L-histidine CAS Number: 305-84-0 Molecular Formula: C9H14N4O3 Molecular Weight: 226.23 Purity: 99% Appearance: White to off-white crystalline powder Optical Rotation [alpha]20: +19 to +23 Melting Point: 250-265C (lit) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. Stable for 6 months after receipt.
Molecular Weight:
226.23
CAS Number:
[305-84-0]
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