Crospovidone is a polymer that is used in the production of tablets and capsules. It is a water-soluble polyvinylpyrrolidone, which is obtained by the condensation of vinyl acetate with pyrrolidine. Crospovidone has been shown to have toxicological properties in vitro, but not in vivo. In vitro studies have demonstrated that crospovidone has no effect on cell lysis or human serum. It also does not inhibit dapagliflozin, an inhibitor of sodium glucose cotransporter 2 (SGLT2), which is a therapeutic target for type 2 diabetes mellitus. Crospovidone has been shown to be effective as a tablet binder in combination with other polymers such as carbopol and hydroxypropyl cellulose (HPC). Synonyms: Polyvinyl polypyrrolidone, crospolividone, Polyvinylpyrrolidone cross-linked CAS No: 25249-54-1 Molecular Formula: (C6H9NO)n Molecular Weight: NA Appearance: White to yellow powder Identity (IR): Conforms to reference Related Substances: N-Vinylpyrrolidone: 0.001% Formic Aci:d: 0.5% Hydrazine: 0.0001% 2-Pyrrolidone: 3% Loss on Drying: 5% Nitrogen: 11-13% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity:
As reported
Form:
White to yellow powder
CAS Number:
[25249-54-1]
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