2,3-Dihydroxybenzoic acid is a phenol that has been found in F. inermis, has antifungal and antioxidant activities, and is an active metabolite of the NSAID and COX inhibitor aspirin and its metabolite salicylic acid. It is formed from salicylic acid by the cytochrome P450 (CYP) isoform CYP2E1 in human liver microsomes. It is active against the opportunistic fungi A. fumigatus, A. flavus, A. niger, and Chrysosporium. Dihydroxybenzoic acid (1 µM) reduces apoptosis, increases autophagy, glutathione (GSH) levels, and superoxide dismutase (SOD) activity, and reduces glutathione peroxidase (GPX) activity in primary rat embryonic H9c2 cardiomyocytes under high-glucose and high-palmitic acid conditions as an in vitro model of diabetic cardiomyopathy. Synonyms: o-Pyrocatechuic Acid, 1,2-Dihydroxybenzene-3-carboxylic Acid, 3-Hydroxysalicylic Acid, Catecholcarboxylic Acid, DHBA, NSC 27435, Pyrocatechuic Acid CAS No: 303-38-8 Molecular Formula: C7H6O4 Molecular Weight: 154.12 Purity: 98% Appearance: Off-white to pink to pale brown powder 1HNMR Spectrum: Conforms to structure Water (KF): As Reported Melting Point: 208-211C (lit) Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Stable for 6 months after receipt.
Molecular Weight:
154.12
CAS Number:
[303-38-8]
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