N-Desethyl sunitinib is an active metabolite of sunitinib. It has been shown to have antitumor response in experimental models, suggesting that it may be a potential biomarker for renal cell cancer. Sunitinib is used in the treatment of cancers such as renal cell cancer and gastrointestinal stromal tumor. N-Desethyl sunitinib has also been shown to affect drug metabolism through the induction of CYP3A4 and CYP2D6, which can lead to drug interactions. This metabolite is detected in human serum by high performance liquid chromatography with a matrix effect analyzer, but not by LC-MS/MS. Synonyms: 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide hydrochloride, N-Desethylsunitinib hydrochloride, N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide hydrochloride, SU 12662 hydrochloride CAS No: 356068-97-8 Molecular Formula: C20H23FN4O2 Molecular Weight: 370.42 Purity: 98% (HPLC) Appearance: White to beige powder Solubility: Yellow, clear Concentration: 2mM Melting Point: 175-179C Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. Under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
370.42
Purity:
98% (HPLC)
Form:
White to beige powder
CAS Number:
[356068-97-8]
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