Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation. Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis. Synonyms: Ethyl gamma-glutamylcysteinylglycinate, Glutathione reduced ethyl ester GSH-MEE, Glutathione Monoethyl Ester, gamma-Glu-Cys-Gly-OEt CAS No: 118421-50-4 Molecular Formula: C21H21N3O6S Molecular Weight: 443.47 Appearance: White to off-white powder Purity: 98% (HPLC) Solubility: Water: 50mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
443.47
Purity:
98% (HPLC)
Form:
White to off-white powder
CAS Number:
[118421-50-4]
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