An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARdelta agonist. Exhibits selectivity for PPARdelta compared to PPARalpha and PPARgamma. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Synonyms: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid, Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid, GW 1516, Endurobol CAS No: 317318-70-0 Molecular Formula: C21H18F3NO3S2 Molecular Weight: 453.5 Appearance: White to yellow powder Purity: 98% Melting Point: 134-144C Solubility: DMSO (Slightly), Methanol (Slightly) Water: 0.5% Storage and Stability: May be stored at 4C for short-term. For long-term storage, aliquot and store at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
453.5
Purity:
98%
Form:
White to yellow powder
CAS Number:
[317318-70-0]
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