Anti-fungal, lanosterol 14alpha-demethylase inhibitor. Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp. Synonyms: (2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, 1-[(2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazole, 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile, BAL 4815, RO 0094815 CAS No: 241479-67-4 Molecular Formula: C22H17F2N5OS Molecular Weight: 437.47 Appearance: White to off-white powder Purity (HPLC): 98% NMR: Conforms to reference 1H-NMR : Conforms to reference Solubility: DMSO: 2mg/ml Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
437.47
Purity:
98% (HPLC)
Form:
White to off-white powder
CAS Number:
[241479-67-4]
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