Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface. Alternate Names: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, GSK 572016, GW-572016, GW 572016X, Tykerb, Tyverb CAS Number: 231277-92-2 Molecular Formula: C29H26ClFN4O4S Molecular Weight: 581.06 Method for Determining Identity: Proton NMR Loss on Drying: 0.5% Heavy Metals: 20ppm Appearance: Pale yellow to yellow powder Purity: 99% (HPLC) Storage and Stability: Store at 4C. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
581.06
Purity:
99% (HPLC)
Form:
Pale yellow to yellow powder
CAS Number:
[231277-92-2]
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