A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) ofnMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54uM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimers disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated bynMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimers disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity). Residue on Ignition: 0.1% Heavy Metals: 0.002% Individual Impurity: 0.5% Total Impurity: 1% Water Content: 1% Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
215.77
Purity:
99.0%
Form:
White to off-white crystalline powder
CAS Number:
[41100-52-1]
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