Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant/chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator. Synonyms: Z-Leu-Leu-Leu-al, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Proteasome Inhibitor XI) CAS Number: 133407-82-6 Molecular Formula: C26H41N3O5 Sequence: Z-Leu-Leu-Leu-aldeyhde Molecular Weight: 475.62 Appearance: White to off-white powder Purity: 98% Melting Point: >68C (dec.) Solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) Storage and Stability: Store at 4CHygroscopic. Under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
475.62
Purity:
98%
Form:
White to off-white powder
CAS Number:
[133407-82-6]
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