An antagonist of muscarinic acetylcholine receptors, anti-spasmodic. An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40nM for human recombinant M1-5, respectively).1 It inhibits intracellular calcium mobilization induced by carbamoylcholine in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1nM, respectively).2 Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089mg/kg, respectively).1 It also increases pupil diameter (PD) and locomotor activity (LMA, ED50s = 0.29 and 0.52mg/kg, respectively) and decreases small intestinal transit (SIT, ID50 = 0.22mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder. Synonyms: alpha-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester hydrochloride, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride, MJ4309-1 CAS No: 1508-65-2 Molecular Formula: C22H32ClNO3 Molecular Weight: 393.95 Appearance: White to off-white crystalline powder Purity: 98% Solubility: Soluble in water (50mg/ml). Methanol (Slightly), Chloroform (Slightly) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
393.95
Purity:
98%
Form:
White to off-white crystalline powder
CAS Number:
[1508-65-2]
* VAT and and shipping costs not included. Errors and price changes excepted
