Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynauds syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo. Synonyms: 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, methanesulfonate CAS No: 65-28-1 Free Base: 50-60-2 Molecular Formula: C18H23N3O4S Molecular Weight: 377.46 Appearance: White to off-white solid Purity: 95% Melting Point: >180C (dec.) Solubility: DMSO (Slightly), Methanol (Slightly) Storage and Stability: Store at 3C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
377.46
Purity:
95%
Form:
White to off-white solid
CAS Number:
[65-28-1]
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