A flavanoid with diverse biological activities. Widespread in plants, e.g. in Salicaceae, Lamiaceae, Moraceae, Compositae, Leguminosae, Rosaceae, Gentianaceae. The commonest of all flavone glycosides. Luteolin-7-O-glucoside and luteolin at concentrations lower than 20 muM, significantly suppresses the productions of nitric oxide and prostaglandin E-2 (PGE(2)) in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity, the inhibitory effects were further attributed to the suppression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression, and not reduced enzymatic activity.[1] Luteolin-7-O-glucoside from Ailanthus altissima has antiasthmatic activity through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model.[2] Luteolin-7-O-Glucoside can induce apoptosis by scavenging ROS and suppressing the expression of beta-catenin in COLO 320 DM cells and effectively inhibit ACF development in DMH-induced experimental carcinogenesis, Hence it can be a potent anticancer drug for colon carcinogenesis.[3] Luteolin-7-O-glucoside and luteolin can inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-kappaB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells.[4] Luteolin-7-O-glucoside has anti-asthmatic activity, can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cgamma1 in activated mouse bone marrow-derived mast cells.[5] Synonyms: 2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl-D-glucopyranoside, Cynaroside, Luteoloside, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-one, Luteolin 7-glucoside, Glucoluteolin, Cinaroside, Cynaroside, Daphneflavonoloside, Flavopurposide CAS No: 5373-11-5 Molecular Formula: C21H20O11 Molecular Weight: 448.38 Appearance: Yellow powder Purity: 95% Analysis Method: HPLC-DAD or/and HPLC-ELSD Identification Method: Mass, NMR Melting Point: Solubility: Storage: 4C. Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage. Prepare and use solutions on the same day. Store the solution as aliquots in tightly sealed vials at -20°C for up to two weeks.
Molecular Weight:
448.38
Purity:
95% (HPLC-DAD or/and HPLC-ELSD)
Form:
Yellow powder
CAS Number:
[5373-11-5]
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