Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4 Synonyms: 2-Amino-9-beta-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one, 2-Amino-6-hydroxy-9-(beta-D-arabinofuranosyl)purine, 9-beta-D-Arabinofuranosylguanine, Arabinoguanosine, Araguanosine, Guanine arabinoside, NSC 76352, ara-Guanosine CAS No: 38819-10-2 Molecular Formula: C10H13N5O5 Molecular Weight: 283.24 Appearance: White to off-white powder Purity: 98% Melting Point: >245C (dec.) Solubility: Aqueous Base (Slightly, Sonicated), DMSO (Slightly) Storage and Stability: Store at -20C under inert atmosphere. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
283.24
Purity:
98%
Form:
White to off-white powder
CAS Number:
[38819-10-2]
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