Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients. Ribavirin is a so-called antimetabolite, i.e. a drug that is chemically similar to naturally occurring metabolites but interfering with normal metabolic pathways. It is an antiviral nucleoside analog to the natural ribonucleoside guanosine (1). Ribavirin is a broad-spectrum antiviral drug, belonging to the group of inosine monophosphate (IMP) dehydrogenase inhibitors (2). Acting as a virostatic agent, ribavirin is used as an effective drug against respiratory syncytial virus (RSV), herpes viruses, influenza viruses type A and B, Hantaan virus, hepatitis C virus, adenoviruses, flavi viruses, reo viruses, and others. Synonym: 1-b-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide CAS Number: 36791-04-5 Molecular Formula: C8H12N4O5 Molecular Weight: 244.2 Form: White to off-white powder Specific Optical Rotation ([alpha]20D: -37.0 - -33.5 Identity (IR): Confoms to structure pH: 4.0 - 6.5 Loss on Drying: 0.5% Residue on Ignition (sulfated): 0.5% Heavy Metals (Pb): 10ppm Storage and Stability: Store at -20C Stable for 6 months after receipt at -20C.
Purity:
98%
Form:
White to off-white powder
CAS Number:
[36791-04-5]
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