20(R)-Ginsenoside Rg3 is a saponin that has been found in P. ginseng and inhibits angiogenesis.1 20(R)-Ginsenoside Rg3 (0.001-1 µM) dose-dependently reduces proliferation, capillary tube branching, and the expression of matrix metalloproteinase-9 (MMP-9) and MMP-2 in human umbilical vein endothelial cells (HUVECs). It reduces tumor cell invasion of MM1 rat hepatoma, B16FE7 mouse melanoma, OC-10 human lung carcinoma, and PSN-1 human pancreatic adenocarcinoma cells in vitro by 89, 73.7, 84.2, and 59.1%, respectively, when used at a concentration of 25 µM.2 However, it does not inhibit the proliferation of MM1 cells when used at concentrations ranging from 1.6 to 64 µM. 20(R)-Ginsenoside Rg3 (20 mg/kg) reduces tumor volume, increases the tumor necrosis rate by approximately 16%, and increases survival in a human Lewis lung carcinoma mouse xenograft model.3 It also reduces the total number of B16-BL6 melanoma cell and 26-M3.1 colon carcinoma cell lung colonies in mice by 27 and 51%, respectively, when administered at a dose of 100 µg.4 Topical administration of 20(R)-ginsenoside Rg3 (0.05% w/v) reduces ear thickness by 47.5% compared with control animals in a mouse model of oxazolone-induced contact dermatitis and reduces expression of COX-2, IL-4, IL-1, IFN, and TNF mRNA by greater than 25%.5 Synonyms: 12beta,20R-dihydroxydammar-24-en-3beta-yl-2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside, 20(R)-Propanaxadiol CAS No: 38243-03-7 Molecular Formula: C42H72O13 Molecular Weight: 785.01 Appearance: White to off-white powder Purity: 97% Solubility: Ethanol (Slightly) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
785.01
Purity:
97%
Form:
White to off-white powder
CAS Number:
[38243-03-7]
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