Lipid A (E. Coli) triethylammonium salt

Product Overview

• Article Name: Lipid A (E. Coli) triethylammonium salt
• Biozol Catalog Number: USB-297377
• Supplier Catalog Number: 297377
• Alternative Catalog Number: USB-297377-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

The Lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane in most Gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic side of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. These complex glycoforms protect bacteria from antibiotics and complement-mediated lysis. The core and O-antigen domains are required for virulence and consequently are present in most clinical and environmental isolates (Raetz, 2007).