WISP1, Recombinant, Human (CCN4, WNT1-Inducible-Signaling Pathway Protein 1, CCN Family Member 4, Wnt-1-Induced Secreted Protein)
Biozol Catalog Number:
USB-298315
Supplier Catalog Number:
298315
Alternative Catalog Number:
USB-298315-10
Manufacturer:
US Biological
Category:
Molekularbiologie
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Recombinant protein corresponding to human WISP1, fused to Fc-domain of human IgG, expressed in insect cell line. Molecular Weight: ~67.3kD Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
