P300, Recombinant, Human, aa1046-1163, His-Tag (E1A Binding Protein p300, EP300, KAT3B, RSTS2, E1A Binding Protein)
Catalog Number:
USB-298437
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| Article Name: | P300, Recombinant, Human, aa1046-1163, His-Tag (E1A Binding Protein p300, EP300, KAT3B, RSTS2, E1A Binding Protein) |
| Biozol Catalog Number: | USB-298437 |
| Supplier Catalog Number: | 298437 |
| Alternative Catalog Number: | USB-298437-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]. Source: Recombinant protein corresponding to aa1046-1163 from human bromodomain E1A binding protein p300, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~15.1kD Applications: Suitable for use in the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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