| Ginsenoside compound K (C-K) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes, C-K acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites.[1] Ginsenoside compound K, the intestinal metabolite of ginseng saponin, has various chemopreventive and chemotherapeutic activities, including anti-tumor activity, C-K suppresses the activation of the NF-kappaB pathway, may become a potential cytotoxic drug in the prevention and treatment of hepatocellular carcinoma( HCC).[2] Ginsenoside compound K shows significant anti-proliferative effects and pro-apoptotic effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM, suggests that C-K could be potentially effective anti-colorectal cancer agent.[3] Ginsenoside CK has anti-cancer effect on NPC cells, C-K-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo.[4] Synonyms: (3beta,12beta)-3,12-Dihydroxydammar-24-en-20-yl beta-D-Glucopyranoside, 20(S)-Protopanaxadiol 20-O-D-Glucopyranoside, 20(S)-Protopanaxadiol 20-O-beta-D-Glucopyranoside, 20-O-beta-D-Glucopyranosyl-20(S)-protopanaxadiol, 20-O-beta-Glucopyranosyl-20(S)-protopanaxadiol, 3-O-Deglucosylginsenoside F2, Compound K, Ginsenoside IH901, Ginsenoside K, Ginsenoside M1, Ginsenoside Compound K, Ginsenoside Metabolite M1, IH 901, LCHK 168, Protopanaxadiol 20-O-Glucoside CAS No: 39262-14-1 Botanical Source: Prod. from saponins of Gynostemma pentaphyllum by endogenous glycosidases Molecular Formula: C36H62O8 Molecular Weight: 622.87 Appearance: White powder Purity: 98% ( HPLC-DAD or/and HPLC-ELSD) Identification (Mass, NMR): Conforms to structure Melting Point: >149C (dec.) Solubility: Methanol (Slightly), Pyridine (Slightly) Storage and Stability: Store at -20C. Hygroscopic., Under inert atmosphere. Store in a well closed container, protected from air and light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
