| O-Methyldauricine is a bisbenzylisoquinoline alkaloid that has been found to have haemodynamic effects, such as stabilizing the heart, when administered in high doses. It can also be used as a competitive antagonist of chloride ions. O-Methyldauricine has been shown to be synthesized by the conversion of daurisoline, which is an aporphine with two methyl groups on the nitrogen atom and one methoxy group on the benzene ring. The synthesis of O-Methyldauricine starts with sodium hydroxide solution and dihydroisoquinoline, followed by treatment with hydrochloric acid in water. This reaction produces daurisoline and hydrogen chloride gas. When the hydrogen chloride gas is bubbled through a solution containing sodium hydroxide and methanol, it converts daurisoline into O-methylated daurisoline. Synonyms: (-)-O-Methyldauricine, (1R)-1-[4-(5-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-[[4-[2-methoxy-5-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-2-methyl-, (1R-isoquinoline, O,O-Dimethylcuspidaline, O,O-Dimethyldauricinoline CAS No: 2202-17-7 Molecular Formula: C39H46N2O6 Molecular Weight: 638.79 Appearance: White to off-white powder Purity: 95% 1H-NMR: Conforms to reference Boiling Point: 717.6C Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
