Onjisaponin B is a triterpenoid saponin that has been shown to have anti-angiogenic effects, neuroprotective properties, and autophagy inducing activity. Onjisaponin B has also been shown to inhibit the production of tumor necrosis factor-alpha (TNF-alpha) in cultured PC12 cells. The anti-inflammatory effects of this compound may be due to its ability to induce autophagy. This compound induces autophagy by activating the mechanistic target of rapamycin (mTOR) pathway, which leads to the induction of autophagy through the activation of AMP kinase. Onjisaponin B has been found in plants used in traditional Chinese medicine and other Asian countries. Synonyms: Senegin III, Sinegin 3, (E)-Senegin III, (2beta,3beta,4alpha)-3-(beta-D-glucopyranosyloxy)-2,27-dihydroxy-olean-12-ene-23,28-dioic acid, 28-[O-6-deoxy-alpha-L-mannopyranosyl-(13)-O-[O-beta-D-galactopyranosyl-(14)-O-beta-D-xylopyranosyl-(14)-6-deoxy-alpha-L-mannopyranosyl-(12)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-beta-D-galactopyranosyl] ester CAS No: 35906-36-6 Molecular Formula: C75H112O35 Molecular Weight: 1573.67 Appearance: White to off-white powder Purity: 95% Solubility: DMSO, Pyridine, Methanol, Ethanol Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
1573.67
Purity:
95%
Form:
White to off-white powder
CAS Number:
[35906-36-6]
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