Sodium aescinate is used as a vasoactive drug in clinical treatment. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-kappaB pathway. Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3]. Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-beta pathway[4]. Synonyms: Escin monosodium salt Botanical Source: Aesculi semen CAS Number: 20977-05-3 Molecular Formula: C55H86NaO23 Molecular Weight: 1124.23 Appearance: White to off-white powder Purity (HPLC-DAD or/and HPLC-ELSD): 90% Identification Method: Mass, NMR Solubility: DMSO (10mg/ml) Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
1124.23
Purity:
90%
Form:
White to off-white powder
CAS Number:
[20977-05-3]
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