The different signal transduction pathways involved in the up-regulation of cAMP by the peptide hormone relaxin (RLX). When relaxin binds to its G protein-coupled receptor, LGR7 or LGR8, a G protein signaling pathway is activated leading to stimulation of adenylate cyclase (AC) and an increase in cAMP. Binding of relaxin to its receptor also may activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase (PDE) that degrades cAMP . Source: aa735-757, Human Molecular Weight: ~2653.0 Sequence: Pro-Asp-Leu-Phe-Thr-Tyr-Pro-Cys-Glu-Met-Ser-Leu-Ile-Ser-Gln-Ser-Thr-Arg-Leu-Asn-Ser-Tyr-Ser Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
2653
Purity:
~95% (HPLC)
Form:
Supplied as a white powder.
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