Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Source: aa177-204, Human Molecular Weight: ~2731.91 Sequence: Met-Tyr-Pro-Ser-Ser-Pro-Glu-Gly-Glu-Gly-Ser-Gly-Leu-Leu-Trp-Ala-Ser-Ala-Ser-Cys-Ser-Glu-Ser-Glu-Gly-Gly-Val-Gly Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
2731.91
Purity:
~96% (HPLC)
Form:
Supplied as a white powder.
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