DDB1 (DNA Damage-Binding Protein 1, DDB p127 Subunit, DNA Damage-Binding Protein a, DDBa, Damage-specific DNA-Binding Protein 1, HBV X-Associated Protein 1, XAP-1, UV-Damaged DNA-Binding Factor, UV-Damaged DNA-Binding Protein 1, U
DDB1 (DNA Damage-Binding Protein 1, DDB p127 Subunit, DNA Damage-Binding Protein a, DDBa, Damage-specific DNA-Binding Protein 1, HBV X-Associated Protein 1, XAP-1, UV-Damaged DNA-Binding Factor, UV-Damaged DNA-Binding Protein 1, U
DDB1 (DNA Damage-Binding Protein 1, DDB p127 Subunit, DNA Damage-Binding Protein a, DDBa, Damage-specific DNA-Binding Protein 1, HBV X-Associated Protein 1, XAP-1, UV-Damaged DNA-Binding Factor, UV-Damaged DNA-Binding Protein 1, U
Biozol Catalog Number:
USB-313152
Supplier Catalog Number:
313152
Alternative Catalog Number:
USB-313152-50,USB-313152-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC, WB
Immunogen:
Synthetic peptide of human DDB1
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:500-1:5000 Western Blot: 1:200-1:500 Immunohistochemistry: 1:25-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
