| Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100ng/ml. Sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT Molecular Weight: 8.7kD PubMed ID: 2923622, 2513477, 2465924, 2518726, 2357211, 1661560, 8107690, 10918580, 14702039, 15489334, 2648385, 2322286, 2071154, 8195247, 8627182, 8898111, 9792674, 9837883, 10587439, 10529171, 15033992, 23233732, 1857712, 8639605, 8989326, 16352737 Gene Name: CCL2, MCP1, SCYA2 Swiss Prot: P13500 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
