Interleukin-1 alpha, active (IL1A), Recombinant, Human
Biozol Catalog Number:
USB-348089
Supplier Catalog Number:
348089
Alternative Catalog Number:
USB-348089-10
Manufacturer:
US Biological
Category:
Molekularbiologie
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of > 1.0x10e9 IU/mg. Sequence: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA Molecular Weight: 18.0kD PubMed ID: 2989698, 3486405, 2994016, 2635664, 3485152, 3493774, 11991722, 14702039, 15815621, 15489334, 3281727, 8346241, 2346741 Gene Name: IL1A,IL1F1 Swiss Prot: P01583 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
