Interleukin-6, active (IL6), Recombinant, Rhesus Macaque

Product Overview

• Article Name: Interleukin-6, active (IL6), Recombinant, Rhesus Macaque
• Biozol Catalog Number: USB-348150
• Supplier Catalog Number: 348150
• Alternative Catalog Number: USB-348150-10,USB-348150-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). Molecular Weight: 21.1kD PubMed ID: 7561102 Gene Name: IL6 Protein Accession Number: UniProt P51494 Amino Acid Sequence, aa28-212: MAPVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1ng/ml, corresponding to a specific activity of >1.0x10e7IU/mg. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O, 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 21.1
• UniProt: P51494
• Purity: 97% (SDS-PAGE) and HPLC. Endotoxin: 1EU/ug protein.
• Form: Supplied as a lyophilized powder from 50mM Tris-HCl, pH 9.0, 600mM sodium chloride and 0.02% Tween-20. Reconstitute with sterile ddH2O, 0.1% BSA to a concentration of 0.1-1mg/ml.