Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. CAS Number: 893449-38-2 Molecular Formula: C17H11Br2NO2S2 Solubility: Organic solvents DMSO and dimethyl formamide (~16mg/ml), which should be purged with an inert gas. Sparingly soluble in aqueous buffers. Molecular Weight: 485.2 Lambda max: 273, 384nm Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
485.2
Purity:
Highly Purified (~98%)
Form:
Supplied as a crystalline solid.
CAS Number:
[893449-38-2]
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