PTP4A1, also known as protein tyrosine phosphatase type IVA 1, is cell signaling molecule that plays regulatory roles in a variety of cellular processes. This protein is a unique nuclear PTP that is induced in regenerating liver and mitogen stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. Source: Recombinant protein corresponding to aa1-170 of human PTP4A1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~21.6kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
