RNF7, Recombinant, Human, aa1-113, His-Tag (RING-box protein 2 isoform 1)
Biozol Catalog Number:
USB-350243
Supplier Catalog Number:
350243
Alternative Catalog Number:
USB-350243-100,USB-350243-500
Manufacturer:
US Biological
Category:
Molekularbiologie
RNF7 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHuK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. Source: Recombinant protein corresponding to aa1-113 of human RNF7, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~15.1kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMADVEDG EETCALASHS GSSGSKSGGD KMFSLKKWNA VAMWSWDVEC DTCAICRVQV MDACLRCQAE NKQEDCVVVW GECNHSFHNC CMSLWVKQNN RCPLCQQDWV VQRIGK Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
