SNRPE, also known as SME, aids in the cytoplasmic construction of the usnRNPs by binding to a conserved Sm site on usnRNA and forming a stable snRNP core complex. As a core protein to usnRNP, the SNRPE associates with the entire u family of snRNAs including u1-u6. SNRPE also interacts with DDX20 and Small nuclear ribonucleoprotein polypeptide F. Source: Recombinant protein corresponding to aa1-92 of human SNRPE, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~12.9kD AA Sequence: MGSSHHHHHH SSGLVPRGSH MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
