TMED10, Recombinant, Human, aa32-185, His-Tag (Transmembrane emp24 domain-containing protein 10)
Biozol Catalog Number:
USB-350333
Supplier Catalog Number:
350333
Alternative Catalog Number:
USB-350333-20, USB-350333-100, USB-350333-250
Manufacturer:
US Biological
Category:
Molekularbiologie
TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complexs gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimers disease. This gene has a pseudogene on chromosome 8. Recombinant protein corresponding to aa32-185 of human TMED10, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~20kD Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
