AKR1C4, Recombinant, Human, aa1-323 (Aldo-keto reductase family 1 member C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA)
Biozol Catalog Number:
USB-351065
Supplier Catalog Number:
351065
Alternative Catalog Number:
USB-351065-20, USB-351065-100
Manufacturer:
US Biological
Category:
Molekularbiologie
AKR1C1 also known as Aldo-keto reductase family 1 member C4, belongs to aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. It catalyzes the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. Source: Recombinant protein corresponding to aa1-323 from human AKR1C4, expressed in E. coli. Molecular Weight: ~37kD (323aa) Specific Activity: >700pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1pmole 1-Acenaphthenol in the presence of NADP/minute at pH 8.8 at 25C. Amino Acid Sequence: MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN RNYRYVVMDF LMDHPDYPFS DEY Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
