CA8, Recombinant, Human, aa1-290, His-Tag (Carbonic anhydrase-related protein, CA-VIII, CALS, CAMRQ3, CARP)
Catalog Number:
USB-351114
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| Article Name: | CA8, Recombinant, Human, aa1-290, His-Tag (Carbonic anhydrase-related protein, CA-VIII, CALS, CAMRQ3, CARP) |
| Biozol Catalog Number: | USB-351114 |
| Supplier Catalog Number: | 351114 |
| Alternative Catalog Number: | USB-351114-20,USB-351114-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| CA8 was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, this protein lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). It continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). Recombinant protein corresponding to aa1-290 from human CA8, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~35.5kD (314aa) Specific Activity: >450pmol/min/ug. Unit Definition: Defined as the amount of enzyme that hydrolyze 1pmole of 4-nitrophenyl acetate to 4-nitrophenol/minute at pH 7.5 at 37C. Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANG EYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVR FHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEIL QDIQYKGKSK TIPCFNPNTL LPDPLLRDYW VYEGSLTIPP CSEGVTWILF RYPLTISQLQ IEEFRRLRTH VKGAELVEGC DGILGDNFRP TQPLSDRVIR AAFQ Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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