GSK3B, Recombinant, Human, aa1-420, His-Tag (Glycogen synthase Kinase-3 beta, GSK-3 beta, Serine/threonine-protein Kinase GSK3B)
Catalog Number:
USB-351266
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| Article Name: | GSK3B, Recombinant, Human, aa1-420, His-Tag (Glycogen synthase Kinase-3 beta, GSK-3 beta, Serine/threonine-protein Kinase GSK3B) |
| Biozol Catalog Number: | USB-351266 |
| Supplier Catalog Number: | 351266 |
| Alternative Catalog Number: | USB-351266-50,USB-351266-250 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| GSK3B, also known as glycogen synthase kinase-3 beta, acts as a negative regulator in the hormonal control of glucose homeostasis. Also, this protein has diverse functions as Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Recombinant protein corresponding to aa1-420 from human GSK3B, fused to His-tag at C-terminal expressed in Baculovirus (insect cell). Uniprot/Accession: P49841 Molecular Weight: ~47.5kD(426aa) Amino Acid Sequence: MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST HHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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