IL6ST, also known as interleukin6 signal transducer, belongs to class 1 cytokine receptor family. Binding of IL-6 (IL-11) to either the membrane-anchored or soluble IL-6R (IL-11R) initiates the association of IL-6 R (IL-11 R) with IL6ST when then undergoes homo-dimerization and signal transduction. Source: Recombinant protein corresponding to aa23-619 from human IL6ST, fused to His-tag at C-terminal expressed in insect cell. Molecular Weight: ~68.9kD (605aa) Amino Acid Sequence: ELLDPCGYIS PESPVVQLHS NFTAVCVLKE SCIVNEGKKM RCEWDRGRET HLETNFTLKS TWTNPSIKSV IILKYNIQYR TKDASTWSQI TLPPFEANGK ILDYEVTLTR WKSHLQNYTV KAPCITDWQQ EDGTVHRTYL RGNLAESKCY SHTEYTLSSL TSDTLYMVRM AAYTDEGGKD KCMDYFHVNA NYIVWKTNHF TIPKEQYTII NRTASSVTFT DIASLNIQLT CNILTFGQLE QNVYGITIIS GLPPEKPKNL EWATHKFADC KAKRDTPTSC TVDYSTVYFV NIEVWVEAEN ALGKVTSDHI NFDPVYKVKP NPPHNLSVIN SEELSSILKL PPEDTASTRS SFTVQDLKPF TEYVFRIRCM KEDGKGYWSD WSEEASGITY EDRPSKAPSF WYKIDPSHTQ GYRTVQLVWK NATKLTVNLT NDRYVATLTV RNLVGKSDAA VLTIPACDFQ ATHPVMDLKA FPKDNMLWVE WTTPRESVKK YILEWCVLSD LITVTPVYAD GPGSPESIKA YLKQAPPSKG PTVRTKKVGK NEAVLEWDQL PVDVQNGFIR NYTIFYRTII GNETAVNVDS GPEFTFTTPK FAQGEIELEH HHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
