INHA, also known as Inhibin alpha, belongs to the TGF-beta family. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Source: Recombinant protein corresponding to aa233-366 from human INHA, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~17kD (155aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MSTPLMSWPW SPSALRLLQR PPEEPAAHAN CHRVALNISF QELGWERWIV YPPSFIFHYC HGGCGLHIPP NLSLPVPGAP PTPAQPYSLL PGAQPCCAAL PGTMRPLHVR TTSDGGYSFK YETVPNLLTQ HC Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
