Macrophage Colony-stimulating Factor 1, Recombinant, Human, aa33-255, His-Tag (CSF1, M-CSF, MCSF, Lanimostim)
Catalog Number:
USB-351357
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| Article Name: | Macrophage Colony-stimulating Factor 1, Recombinant, Human, aa33-255, His-Tag (CSF1, M-CSF, MCSF, Lanimostim) |
| Biozol Catalog Number: | USB-351357 |
| Supplier Catalog Number: | 351357 |
| Alternative Catalog Number: | USB-351357-50 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| CSF1, also known as macrophage colony-stimulating factor 1, is a hematopoietic growth factor that is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. It is a four alpha-helical bundle cytokine and its active form is found extracellularly as a disulfide linked homodimer. This protein plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF1 can have differential effects in inflammation and immunity. Recombinant protein corresponding to aa33-255 from human CSF1, fused to His-tag at C-terminal expressed in insect cell. Molecular Weight: ~26.1kD (231aa) Amino Acid Sequence: EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQD VVTKPDCNCL YPKAIPSSDP ASVSPHQPLA PSMAPVAGLT WEDSEGTEGS SLLPGEQPLH TVDPGSAKQR PPRLEHHHHH H Biological Activity: Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 range <3ng/ml. Endotoxin: <1EU/1ug (LAL) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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