MPZL1, Recombinant, Human, aa38-162, His-Tag (Myelin protein zero-like protein 1 Isoform b, MPZL1b, PZR, PZR1b, PZRa, PZRb)
Biozol Catalog Number:
USB-351373
Supplier Catalog Number:
351373
Alternative Catalog Number:
USB-351373-50,USB-351373-250
Manufacturer:
US Biological
Category:
Molekularbiologie
MPZL1 is a cell surface receptor, which is involved in signal transduction processes. This protein recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role, it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. Recombinant protein corresponding to aa38-162 from human MPZL1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~16.1kD (148aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
