TIFA, Recombinant, Human, aa1-184, His-Tag (TRAF-interacting protein with FHA Domain- containing protein A, T2BP, T6BP, TIFAA)
Biozol Catalog Number:
USB-351520
Supplier Catalog Number:
351520
Alternative Catalog Number:
USB-351520-50,USB-351520-250
Manufacturer:
US Biological
Category:
Molekularbiologie
TIFA, also known as TRAF-interacting protein with FHA domain-containing protein A, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. This protein induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. Recombinant protein corresponding to aa1-184 from human TIFA, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~24kD (208aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMTSFED ADTEETVTCL QMTVYHPGQL QCGIFQSISF NREKLPSSEV VKFGRNSNIC HYTFQDKQVS RVQFSLQLFK KFNSSVLSFE IKNMSKKTNL IVDSRELGYL NKMDLPYRCM VRFGEYQFLM EKEDGESLEF FETQFILSPR SLLQENNWPP HRPIPEYGTY SLCSSQSSSP TEMDENES Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
